The expression of specific genes is a highly-regulated process with many levels and stages of control.
This complexity ensures the proper expression in the proper cell at the proper time.
In this section, you will learn about the various methods of gene regulation and the mechanisms used to control geneexpression, such as: epigenetic, transcriptional, post-transcriptional, translational, and post-translational controls in eukaryotic geneexpression, and transcriptional control in prokaryotic geneexpression.
Geneexpression is a highly complex, regulated process that begins with DNA transcribed into RNA, which is then translated into protein.
However, in colon cancer cells, expression of the long form results in increased cell growth instead of cell death.
New Drugs to Combat Cancer: Targeted Therapy Scientists are using what is known about the regulation of geneexpression in disease states, including cancer, to develop new ways to treat and prevent disease development.
Many scientists are designing drugs on the basis of the geneexpression patterns within individual tumors.
With an increased understanding of gene regulation and gene function, medicines can be designed to specifically target diseased cells without harming healthy cells.
Undoubtedly, more targeted therapies will be developed as scientists learn more about how geneexpression changes can cause cancer .
RNA splicing, the first stage of post-transcriptional control Geneexpression is the process that transfers genetic information from a gene made of DNA to a functional gene product made of RNA or protein.
In order to ensure that the proper products are produced, geneexpression is regulated at many different stages during and in between transcription and translation.
In eukaryotes, the gene contains extra sequences that do not code for protein.
Alternative splicing allows more than one protein to be produced from a gene and is an important regulatory step in determining which functional proteins are produced from geneexpression.
Alternative Splicing Alternative splicing is a process that occurs during geneexpression and allows for the production of multiple proteins (protein isoforms) from a single gene coding.
RNA splicing allows for the production of multiple protein isoforms from a single gene by removing introns and combining different exons.
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