minimum inhibitory concentration(noun)
Definition of minimum inhibitory concentration
This is the lowest concentration of an antimicrobial drug that prevents visible growth of a microorganism after overnight incubation with media.
Examples of minimum inhibitory concentration in the following topics:
- Definition and Measurement In microbiology, minimum inhibitory concentration (MIC) is the lowest concentration of an antimicrobial (like an antifungal, antibiotic or bacteriostatic) drug that will inhibit the visible growth of a microorganism after overnight incubation.
- The minimum inhibitory concentration of the antibiotic is between the concentrations of the last well in which no bacteria grew and the next lower dose, which allowed bacterial growth.
- This is important because populations of bacteria exposed to an insufficient concentration of a particular drug or to a broad-spectrum antibiotic (one designed to inhibit many strains of bacteria) can evolve resistance to these drugs.
- Minimum Inhibitory Concentration is the lowest drug concentration that prevents visible microorganism growth after overnight incubation.
- The MBC (minimum bactericidal concentration) is the minimum concentration of drug which can kill the microorganism.
- The MIC (minimum inhibitory concentration) is the minimum concentration of drug which can inhibit the growth of the microorganism.
- Because the concentration of antibiotic that diffuses into the media decreases with increasing distance from the source, a larger zone of inhibition around an antibiotic-containing disk indicates that the bacteria are more sensitive to the antibiotic in the disk.
- The size of a zone of inhibition in a KB test is inversely related to the minimum inhibitory concentration (MIC), which is the amount of antibiotic required to prevent bacterial growth in an overnight culture.