Anatomy and Location The adrenal medulla is the core of the adrenal glands , and is surrounded by the adrenalcortex.
The cells migrate a second time to the adrenal medulla.
The adrenal medulla produces Catecholamines, derived from the amino acid tyrosine.
The adrenal medulla secretes approximately 20% norepinephrine and 80% epinephrine.
Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related (though less common) tumors that originate in the ganglia of the sympathetic nervous system; they are named based upon the primary anatomical site of origin.
The adrenalcortex is devoted to the synthesis of corticosteroid and androgen hormones.
The body's stress response is mediated by interplay between the sympathetic nervous system (SNS) and the hypothalmic-pituitary-adrenal (HPA) axis .
This response is also referred to as the sympatho-adrenal response of the body owing to the fact that the preganglionic sympathetic fibers that end in the adrenal medulla secrete acetylcholine, which activates the release of adrenaline and noradrenaline from the medulla.
This response acts primarily on the cardiovascular system and is mediated directly via impulses transmitted through the sympathetic nervous system and indirectly via catecholamines secreted from the adrenal medulla.
ACTH acts on the adrenal cortices which produce glucocorticoid hormones, like cortisol, which is a stress hormone which exerts many effects throughout the body.
ACTH is then transported through the circulatory system to the adrenalcortex where it promotes the biosynthesis of corticosteroids like cortisol and cholesterol.
The body's stress response is mediated by the sympathetic nervous system and the hypothalmic-pituitary-adrenal (HPA) axis.