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White matter is one of the two components of the central nervous system and consists mostly of glial cells and myelinated axons that transmit signals both from one region of the cerebrum to another and between the cerebrum and lower brain centers.
White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid tissue veined with capillaries .
Its white color is due to its usual preservation in formaldehyde.
White matter, long thought to be passive tissue, actively affects how the brain learns and dysfunctions.
While grey matter is primarily associated with processing and cognition, white matter modulates the distribution of action potentials, acting as a relay and coordinating communication between different brain regions.
White matter is composed of bundles of myelinated nerve cell processes (or axons), which connect various grey matter areas (the locations of nerve cell bodies) of the brain to each other and carry nerve impulses between neurons.
Myelin acts as an insulator, increasing the speed of transmission of all nerve signals.
The total number of long range fibers within a cerebral hemisphere is 2% of the total number of cortico-cortical fibers and is roughly the same number as those that communicate between the two hemispheres in Corpus callosum.
Schüz and Braitenberg note that "as a rough rule, the number of fibres of a certain range of lengths is inversely proportional to their length.
There are three different kinds of tracts, or bundles of axons, which connect one part of the brain to another within the white matter:
Projection tracts extend vertically between higher and lower brain and spinal cord centers, and carry information between the cerebrum and the rest of the body.
Other projection tracts carry signals upward to the cerebral cortex.
Superior to the brainstem, such tracts form a broad, dense sheet called the internal capsule between the thalamus and basal nuclei, then radiate in a diverging, fanlike array to specific areas of the cortex.
Commissural tracts cross from one cerebral hemisphere to the other through bridges called commissures.
The great majority of commissural tracts pass through the large corpus callosum.
A few tracts pass through the much smaller anterior and posterior commissures.
Commissural tracts enable the left and right sides of the cerebrum to communicate with each other.
Association tracts connect different regions within the same hemisphere of the brain.
Long association fibers connect different lobes of a hemisphere to each other, whereas short association fibers connect different gyri within a single lobe.
Among their roles, association tracts link perceptual and memory centers of the brain.
The brain in general (and especially a child's brain) can adapt to white-matter damage by finding alternative routes that bypass the damaged white-matter areas, and can therefore maintain good connections between the various areas of gray matter.
The corpus callosum (Latin: "tough body"), also known as the colossal commissure, is a wide, flat bundle of neural fibers beneath the cortex in the eutherian brain at the longitudinal fissure.
It connects the left and right cerebral hemispheres and facilitates interhemispheric communication.
It is the largest white matter structure in the brain, consisting of 200–250 million contralateral axonal projections.
The posterior portion of the corpus callosum is called the splenium; the anterior is called the genu (or "knee"); between the two is the truncus, or "body," of the corpus callosum.
The part between the body and the splenium is often markedly thinned and thus referred to as the "isthmus.
" The rostrum is the part of the corpus callosum that projects posteriorly and inferiorly from the anteriormost genu, as can be seen on the sagittal image of the brain displayed on the right.
The rostrum is so named for its resemblance to a bird's beak.
Agenesis of the corpus callosum (ACC) is a rare congenital disorder in which the corpus callosum is partially or completely absent.
ACC is usually diagnosed within the first two years of life and may manifest as a severe syndrome in infancy or childhood, as a milder condition in young adults, or as an asymptomatic incidental finding.
Initial symptoms of ACC usually include seizures, which may be followed by feeding problems and delays in holding the head erect, sitting, standing, and walking.
Other possible symptoms may include impairments in mental and physical development, hand-eye coordination, and visual and auditory memory.
Hydrocephaly may also occur.
In mild cases, symptoms such as seizures, repetitive speech, or headaches may not appear for years.
Source: Boundless. “White Matter of the Cerebrum.” Boundless Anatomy and Physiology. Boundless, 14 Nov. 2014. Retrieved 20 Mar. 2015 from https://www.boundless.com/physiology/textbooks/boundless-anatomy-and-physiology-textbook/central-nervous-system-cns-12/cerebral-cortex-or-cerebral-hemispheres-120/white-matter-of-the-cerebrum-651-9361/