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Keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 95% of the cells found there.
Those keratinocytes found in the basal layer (Stratum germinativum) of the skin are sometimes referred to as "basal cells" or "basal keratinocytes.
Merkel cells or Merkel-Ranvier cells are oval receptor cells found in the skin of vertebrates that have synaptic contacts with somatosensory afferents.
They are associated with the sense of light touch, discrimination of shapes, and textures.
The epidermis is the outermost layer of the skin . It forms a protective barrier over the body's surface which prevents pathogens from entering . It is also responsible for retaining water in the body and absorbing nutrients.
Skin layers, of both hairy and hairless skin.
This image details the parts of the integumentary system.
The epidermis is the outermost layer and helps the skin regulate body temperature. It does not contain any blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis.
The epidermis can be further subdivided into five strata or layers:
Stratum corneum - corneocytes are surrounded by a protein envelope (cornified envelope proteins), filled with water-retaining keratin proteins, attached together through corneodesmosomes and surrounded in the extracellular space by stacked layers of lipids.
Stratum lucidum (only on palms and soles of feet).
Stratum granulosum - in this layer, keratinocytes lose their nuclei and their cytoplasm appears granular. Lipids, contained in these keratinocytes within lamellar bodies, are released into the extracellular space through exocytosis to form a lipid barrier.
Stratum spinosum - Langerhans cells, immunologically-active cells, are located in the middle of this layer.
The epidermis is made up of 95% keratinocytes but also contains melanocytes, Langerhans cells, Merkel cells, and inflammatory cells.The stratum basale is primarily made up of basal keratinocyte cells, which can be considered the stem cells of the epidermis. They divide to form the keratinocytes of the stratum spinosum, which migrate superficially.
The epidermis consists of stratified squamous keratinizing epithelium, composed of proliferating basal and differentiated suprabasal keratinocytee, with an underlying basement membrane. Keratinocytes are the major cells, constituting 95% of the epidermis, while Merkel cells, melanocytes, and Langerhans cells are also present.
Keratinocytes in the stratum basale proliferate during mitosis and the daughter cells move up the strata, changing shape and composition as they undergo multiple stages of cell differentiation to eventually become anucleated. During that process keratinocytes will become highly organized, forming cellular junctions (desmosomes) between each other and secreting keratin proteins that aid in protection, and lipids which contribute to the formation of an extracellular matrix which serves to provide mechanical strength to the skin.
Keratinocytes from the stratum corneum are eventually shed from the surface (desquamation). This process is called keratinization and takes place within about 30 days.